Cluster of Differentiation 14 (CD14) is a macrophage-derived monocyte marker that stains granulocytes, endothelial and epithelial cells, placental trophoblasts, and the red pulp and marginal zone cells of the spleen. In lymph nodes, sinusoidal histiocytes and follicular dendritic cells stain positively for CD14, while monocyte-derived cells, including macrophages associated with anthracosis and sinusoidal histiocytosis with erythrophagocytosis, stain negatively. High CD14 expression is found in histiocytes with Diffuse Large B-Cell Lymphoma (DLBCL) when compared to Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL), Mantle Cell Lymphoma (MCL), or Follicular Lymphoma (FL). CD14 is also valuable for differentiating between acute monocytic leukemia, myeloproliferative neoplasms, and myelodysplastic syndrome.

• IHC014-CD14 Datasheet-RUO

• MSDS

CLONE:
IHC014

ISOTYPE:


HOST SPECIES:
Rabbit

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Tonsil, Lymph Node, Appendix, Myeloid Leukemia

DILUTION RANGE:


INTENDED USE/REG. STATUS:
RUO