Cytokeratin 5 dimerizes with Cytokeratin 14 to form the cytoskeleton of basal epithelial cells, while Cytokeratin 6 multimerizes with Cytokeratin 16 and/or 17 in the tongue, oral epithelia and esophagus, hair follicles, and glandular epithelia. Anti-Cytokeratin 5 & 6 rarely stains lung adenocarcinoma, but will produce small foci or scattered staining patterns in these Cytokeratin 5 & 6(+) samples. Cytokeratin 5 & 6 staining is useful for identifying squamous cell carcinoma, and can be used to determine the malignancies of myoepithelial cells in the breast and prostate. Cytokeratin 5 & 6 also rarely stains carcinomas of the breast, colon, and prostate. A panel of antibodies against Cytokeratin 5 & 6, TTF-1, napsin A, p63, SOX2, DSC3, and desmoglein-3 is useful for differentiating lung squamous cell carcinoma from lung adenocarcinoma and large cell carcinoma.

• 2021 NordiQC Assessment Report for IHC556: Good
• IHC556-Cytokeratin 5/6 Datasheet-IVD

• MSDS

CLONE:
IHC556

ISOTYPE:
IgG1

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Lung Squamous Cell Carcinoma, Mesothelioma

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVD

ADDITIONAL INFORMATION:
NordiQC Rating: Good (Assessment Run 63 2021)