GeneAb™ PAX-8 [IHC048] on Ovarian Cancer
GeneAb™ PAX-8 [IHC048] on Ovarian Cancer
PAX-8

CAT. NO. IHC048
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Description

PAX-8 is expressed in simple ovarian inclusion cysts and non-ciliated mucosal cells of the fallopian tubes, but is absent from normal ovarian surface epithelial cells. Mutations in the PAX-8 gene are linked to thyroid follicular carcinomas, atypical thyroid adenomas, and thyroid dysgenesis. Reports have associated PAX-8 expression with renal carcinoma, nephroblastoma, and seminoma, and have indicated PAX-8 as a useful marker for renal epithelial tumours, ovarian cancer, and for differential diagnoses in lung and neck tumours. Anti-PAX-8 can be useful in determining the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast, when used in adjunct with a panel of organ-specific markers such as uroplakin, mammaglobin, and TTF-1.

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Specifications

CLONE:
IHC048

ISOTYPE:
IgG

HOST SPECIES:
Rabbit

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Ovarian Carcinoma (Non-Mucinous Carcinoma), Thyroid Carcinoma, Renal Cell Carcinoma

DILUTION RANGE:


INTENDED USE/REG. STATUS:
RUO

ADDITIONAL INFORMATION:
NordiQC Rating: Optimal (Assessment Run 62 2021 and Run 64 2022))


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