GeneAb™ PD-1 [IHC001] on Tonsil
GeneAb™ PD-1 [IHC001] on Tonsil
PD-1

CAT. NO. IHC001
FORMAT
VOLUME
PRICE
N/A
QUANTITY
<
1
<
*The listed price is an estimate only.
Description

Programmed Death 1 (PD-1) is a member of the CD28/CTLA-4 family of T-cell regulators, expressed as a co-receptor on the surface of activated T-cells, B-cells, and macrophages. New studies have suggested that the PD-1/PD-L1 signaling pathway may be linked to anti-tumour immunity, as PD-L1 has been shown to induce apoptosis of activated T-cells or inhibit activity of cytotoxic T-cells. In comparison to CD10 and Bcl-6, PD-1 is expressed by fewer B-cells and has therefore been considered a more specific and useful diagnostic marker for angioimmunoblastic T-cell lymphoma. Therapies targeted toward the PD-1 receptor have shown remarkable clinical responses in patients with various types of cancer, including non-small-cell lung cancer, melanoma, and renal-cell cancer.

Documents
DATASHEETS
OTHERS
Specifications

CLONE:
IHC001

ISOTYPE:
IgG2b

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Tonsil, Lymph Node

DILUTION RANGE:
1:200

INTENDED USE/REG. STATUS:
CE-IVD


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